Dianabol 8R,9S,10S,13S,14S,17S-17-hydroxy-10,13

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Disease Relevance of Metandienone (Stanozolol)

Metandienone is a synthetic anabolic–androgenic steroid (AAS) derived from dihydrotestosterone. While it has therapeutic uses in certain medical conditions, its impact on health is significant:

Medical Use	Condition	Rationale
Hormone replacement therapy	Hypogonadism, low testosterone	Restores androgen levels, improves libido and energy
Anemia treatment	Certain anemias	Stimulates erythropoiesis (red blood cell production)

However, the drug’s side‑effect profile limits its clinical utility:

Hepatotoxicity: Oral AAS can cause cholestatic liver injury and hepatic adenomas.

Cardiovascular risks: Elevated LDL cholesterol, hypertension, increased risk of thromboembolic events.

Endocrine disturbances: Suppression of the hypothalamic‑pituitary‑gonadal axis, gynecomastia, infertility.

Psychiatric effects: Aggression ("roid rage"), https://gitea.offends.cn mood swings, depression.

In addition, misuse and abuse are common among athletes, bodybuilders, and adolescents seeking performance enhancement or aesthetic improvement. The illicit use of AAS is associated with long‑term health consequences, including irreversible endocrine disorders, cardiovascular disease, hepatic dysfunction, and psychiatric sequelae.

Clinical Relevance

Diagnosis: Requires careful history taking, physical examination, and laboratory evaluation (serum testosterone, LH, FSH, estradiol). Imaging may be needed to detect testicular atrophy or tumors.

Management: Hormonal replacement therapy, counseling for substance misuse, lifestyle modification, monitoring of cardiovascular risk factors. In cases of abuse, psychiatric support is essential.

Prevention: Public education on the risks of AAS; regulation of supplements; routine screening in athletes and bodybuilders.

The review by Cohen et al. (2022) provides a comprehensive synthesis of current knowledge regarding endocrine alterations induced by anabolic steroid use, highlighting gaps in understanding and areas for future research. This article serves as an essential resource for clinicians, researchers, and public health professionals addressing the complex interplay between anabolic steroids and male reproductive endocrinology.");">Metandienone

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